We found insufficient evidence to determine whether there was any clear difference between the groups in miscarriage rates in gonadotrophin-stimulated cycles OR 1. We found insufficient evidence to determine whether there was any clear difference in clinical pregnancy rates between ICI timed after a rise in urinary levels of LH versus a rise in basal temperature plus cervical mucus scores OR 1.
Neither of these studies reported multiple pregnancy or miscarriage rates as outcomes. Authors' conclusions: There was insufficient evidence to determine whether there was a clear difference in live birth rates between IUI and ICI in natural or gonadotrophin-stimulated cycles in women who started with donor sperm treatment.
Very low-quality data suggested that in gonadotrophin-stimulated cycles, ICI may be associated with a higher clinical pregnancy rate than IUI, but also with a higher risk of multiple pregnancy rate. Ideally, the fertilized egg would then implant in the lining of the uterus, resulting in pregnancy and delivery of a full-term baby or babies.
Artificial insemination is considerably less expensive than IVF and less invasive. IVF and IUI have a few factors in common, and they mostly have to do with preparing for treatment and the basic processes of human conception. Before insemination or fertilization, both IUI and IVF may include a regimen of fertility drugs to increase success rates in fertilization or in the case of IVF, to assist in ovulation and aid in egg retrieval.
Also, both treatments can include processes to isolate the highest quality sperm from provided samples for use in fertilization. For both IVF and IUI to be successful, an egg must be fertilized and then implant in the lining of the uterus and develop into a full-term infant, or multiple infants.
As discussed before, IUI, or artificial insemination, is the more common fertility treatment. Other than the fact that it is often the first treatment many people try, this is because it is less invasive and fertilization happens internally, not in a lab. Because of this, artificial insemination requires working ovaries, viable eggs and fallopian tubes and availability of motile sperm after the ejaculate of the male partner is processed. Very low-quality data suggested that in gonadotrophin-stimulated cycles, IUI may be associated with a higher clinical pregnancy rate than ICI, but also with a higher risk of multiple pregnancy rate.
We concluded that the current evidence was too limited to choose between IUI or ICI, in natural cycles or with ovarian stimulation, in donor sperm treatment. The first-line treatment in donor sperm treatment consists of inseminations that can be done by intrauterine insemination IUI or by intracervical insemination ICI.
To compare the effectiveness and safety of intrauterine insemination IUI and intracervical insemination ICI in women who start donor sperm treatment. We included cross-over studies if pre-cross-over data were available. We used standard methodological procedures recommended by Cochrane. We collected data on primary outcomes of live birth and multiple pregnancy rates, and on secondary outcomes of clinical pregnancy, miscarriage, and cancellation rates.
There was very low-quality evidence; the main limitations were risk of bias due to poor reporting of study methods, and serious imprecision. There was insufficient evidence to determine whether there was any clear difference in live birth rate between IUI and ICI in natural cycles odds ratio OR 3.
There was only one live birth in this study in the IUI group. IUI resulted in higher clinical pregnancy rates OR 6. There was insufficient evidence to determine whether there was any clear difference in live birth rate between IUI and ICI in gonadotrophin-stimulated cycles OR 2.
We found insufficient evidence to determine whether there was any clear difference between the groups in miscarriage rates in gonadotrophin-stimulated cycles OR 1.
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